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OBJECTIVE:To determine the therapeutic effect of Ziyin Jianghuo Ningxin Decoction (ZYJHNXD) plus dehydroepiandrosterone (DHEA) and menopausal hormone therapy (MHT) in patients suffering from menopausal symptoms identified as,in terms of Traditional Chinese Medicine,symptom patt of Yin deficiency with hyperactive fire.METHODS:Totally 180 postmenopausal women aged 40 to 60 years were assigned into four groups and accepted femoston,femoston with ZYJHNXD,femoston with DHEA,femoston with ZYJHNXD and DHEA therapies,respectively,for three months.Common questionnaire-based measure instruments included modified Kupperman index (MKI),Hamilton Rating Scale for Anxiety (HAMA),and Hamilton Rating Scale for Depression (HAMD).Follicle-stimulating hormone (FSH),luteinizing hormone (LH),estradiol (E2),5-hydroxyindole-3-acetic acid (5-HIAA),norepinephrine (NE),dopamine (DA),bone mineral density (BMD),and sleep quality were evaluated before and three months after the treatments.RESULTS:In all four groups,the scores of MKI,HAMA,HAMD and the levels of FSH,LH decreased significantly (P ＜ 0.05) after the treatment,while the levels of E2,5-HIAA,NE,and DA showed obvious elevation (P ＜ 0.05).The group receiving ZYJHNXD and DHEA combined with femoston had superiority in the preservation of bone mineral density and improvement of total sleep time and nighttime sleep time over the other three groups.CONCLUSION:ZYJHNXD and DHEA combined with MHT therapy have a favorable outcome in managing menopausal symptoms,restoring hormone levels,preventing skeletal rarefaction or osteoporosis,and improving sleep quality for postmenopausal women.