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目的 评价１５３Ｓｍ － 乙二胺四亚甲基膦酸（ＥＤＴＭＰ） 治疗骨转移癌的临床价值。方法 ４５ 例临床上确诊为恶性肿瘤伴多发性骨转移患者，其中男１６ 例，女２９ 例，年龄３１ ～７６ 岁，均有显著骨痛。采用两次给药法静脉注射１５３Ｓｍ － ＥＤＴＭＰ。结果 治疗后骨痛完全缓解者２０ 例（４４．４ ％ ） ，骨痛部分缓解者２２ 例（４８．９ ％ ） ，无效者３ 例（６．７ ％ ），止痛总有效率为９３．３％ 。转移灶缩小或消失总有效率为２６．７ ％ 。结论 １５３Ｓｍ － ＥＤＴＭＰ治疗骨转移癌有一定的临床价值。
Objective To evaluate the clinical value of 153Sm-ethylenediaminetetramethylenephosphonic acid (EDTMP) in the treatment of bone metastases. Methods Forty-five patients were diagnosed as having malignant tumors with multiple bone metastases, including 16 males and 29 females, aged 31 to 76 years. All had significant bone pain. 153Sm - EDTMP was intravenously injected twice. Results Twenty patients (44.4%) had complete remission of bone pain after treatment, 22 (48.9 %) had partial remission of bone pain, and 3 (6.7%) had no effect. The total effective rate of analgesia was 93.3. %. The total effective rate of metastasis shrinkage or disappearance was 26.7%. Conclusion 153Sm-EDTMP has certain clinical value in the treatment of bone metastases.