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目的 探讨神经肽Y(neuropeptideY ,NPY)与新生儿窒息的关系。 方法 采用放射免疫法测定 37例有新生儿窒息孕妇 (窒息组 )及 33例正常妊娠妇女 (对照组 )静脉血及脐血中NPY含量。 结果 (1)窒息组脐血中NPY含量为 (187.4 7± 4 6 .6 3)ng/L ,对照组为 (115 .33±2 9.4 2 )ng/L。两组比较差异有显著性 (t =3.113,P <0 .0 1) ,重度窒息组与轻度窒息组间差异也有显著性(t=2 .0 0 1,P <0 .0 5 )。 (2 )窒息组母血浆NPY含量为 (78.94± 19.5 2 )ng/L ,对照组为 (85 .73±2 2 .95 )ng/L ,两组间差异无显著性 (t =1.72 1,P >0 .0 5 ) ,且轻、重度窒息组间差异也无显著性 (t =1.5 12 ,P >0 .0 5 )。(3)窒息组脐动脉血血气分析 :pH为 (7.0± 0 .1) ,PO2 为 (1.2± 0 .3)kPa ,PCO2为 (8.9± 0 .8)kPa ;NPY水平与脐血pH及PO2 显著负相关 (r =- 0 .4 5 1及 - 0 .4 92 ,P <0 .0 1) ,与PCO2 显著正相关 (r =0 .4 38,P <0 .0 1)。两组母血NPY水平无差异。 结论 NPY参与了新生儿窒息的病理变化过程 ,与新生儿窒息的发生发展密切相关。
Objective To investigate the relationship between neuropeptide Y (NPY) and neonatal asphyxia. Methods Radioimmunoassay was used to determine the content of NPY in venous blood and cord blood of 37 neonates with asphyxia (asphyxia group) and 33 normal pregnant women (control group). Results (1) NPY content in ascites group was (187.4 7 ± 46.63) ng / L and (115.33 ± 2 9.42) ng / L in control group. The difference between the two groups was significant (t = 3.113, P <0.01). There was also significant difference between severe asphyxia group and mild asphyxia group (t = 2.001, P <0.05). (2) The NPY content of asphyxia group was (78.94 ± 19.52) ng / L and that of the control group was (85.73 ± 2.29) ng / L, with no significant difference between the two groups (t = 1.72 1, P> 0.05), and there was no significant difference between mild and severe asphyxia groups (t = 1.512, P> 0.05). (3) Asphyxia group, umbilical arterial blood gas analysis: pH was (7.0 ± 0.1), PO2 was (1.2 ± 0.3) kPa, PCO2 was (8.9 ± 0.8) kPa; NPY level and umbilical cord blood pH and PO2 (r = -0.454 and -0.42, P <0.01), and had a significant positive correlation with PCO2 (r = 0.38, P <0.01). There was no difference in NPY levels between the two groups. Conclusion NPY is involved in the pathological changes of neonatal asphyxia, which is closely related to the occurrence and development of neonatal asphyxia.