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通过跟踪分离活性成分 ,从粗叶悬钩子RubusaleaefoliusPoir .中分到一个新的鞣花酸鞣质化合物 1和两个已知的没食子酸鞣质 1,2 ,3,6 tetra O galloyl β D glucopyranose(2 )和 1,2 ,3,4 ,6 penta O galloyl β D glucopyranose(3) ,并通过谱学手段确定了新化合物 1的化学结构。化合物 1～ 3将tsFT2 10癌细胞的细胞周期抑制在G0 /G1期 ,MIC值分别为2 2 1μmol·L-1(1) ,7 9μmol·L-1(2 )和 6 6 μmol·L-1(3) ,系三个新的G0 /G1期抑制剂。化合物 1～ 3作为鞣质类化合物的细胞周期抑制剂亦属首例 ,也是从粗叶悬钩子中分到的鞣质类化合物的首次报道
By following the separation of the active ingredient, a new ellagic acid tannin compound 1 and two known gallium gallate 1,2,3,6 tetra O galloyl β D glucopyranose are obtained from Rubus aleolius Poir. 2) and 1,2,3,4,6 penta O galloyl β D glucopyranose (3) , and the chemical structure of the new compound 1 was determined by spectroscopic methods. Compounds 1-3 inhibited the cell cycle of tsFT2 10 cancer cells in the G0/G1 phase with MIC values of 221 μmol·L-1 (1), 79 μmol·L-1 (2) and 6 6 μmol·L- 1(3) is three new G0/G1 phase inhibitors. Compounds 1-3 are also the first case of cell cycle inhibitors that are tannin compounds, and they are also the first reports of tannin compounds that were isolated from the crude leaf raspberry.