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目的对镉观察对象停止镉作业后进行跟踪调查,探讨镉超标与肾功能损害的关系。方法自2005年7月—2011年7月,对惠州市某镍镉电池厂371名工人停止镉作业的镉观察对象跟踪观察7年,分析尿镉、尿β2-微球蛋白(β2-MG)、尿视黄醇结合蛋白的变化规律。结果镉观察对象停止镉作业后,2005—2011年尿镉均值与2004年相比,差异有统计学意义(P<0.05)。尿β2-MG、尿视黄醇结合蛋白有所下降,但差异均无统计学意义(均P>0.05)。结论镉观察对象停止镉作业7 a后,体内镉负荷明显下降,但仍超标,停止镉作业后一般不会造成肾脏的进一步损害。
Objective To investigate the effect of excessive cadmium on renal dysfunction after follow-up investigation of cadmium in cadmium patients. Methods From July 2005 to July 2011, 371 workers who stopped cadmium in a Ni-Cd battery factory in Huizhou City were followed up for 7 years. Urinary cadmium and urine β2-microglobulin (β2-MG) , Urinary retinol binding protein changes. Results After cadmium administration was stopped, the urinary cadmium average value in 2005-2011 was significantly different from that in 2004 (P <0.05). Urinary β2-MG, urinary retinol binding protein decreased, but the difference was not statistically significant (all P> 0.05). Conclusions The cadmium load in cadmium cadmium significantly decreased after 7 days of cadmium treatment. However, the cadmium load was still excessive. After stopping cadmium treatment, cadmium load would not cause further damage to the kidneys.