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1981年春季西班牙发生了一种累及多系统的疾病,流行病学调查表明该病与食入变性菜籽油有关。主要症状开始表现为胸膜和肺部病变,肌肉痛,嗜酸细胞增多,皮疹。随着病程的进展,可发生静脉和毛细血管的炎症。变性菜籽油中含有一种油酰苯胺(oleoylanilide)的物质,它主要的靶器官是肺脏和脂肪组织,并能改变该组织中的脂肪代谢。油苯酰胺还能改变细胞膜的通透性,使花生四烯酸从细胞膜的磷脂中释放出来。花生四烯酸在环加氧酶的作用下转变为脂质过氧化物如丙二醛,还可以产生过氧化自由基的形式。作者以变性菜籽油喂养大鼠,并测定其肝脏、肺脏和肾脏组织中的丙二醛及谷胱甘肽含量,与对照组比较,变
In the spring of 1981 there was a multi-system disease in Spain, and epidemiological investigations showed that it was associated with the ingestion of degenerated rapeseed oil. The main symptoms begin to manifest as pleura and lung lesions, muscle pain, eosinophilia, and rash. As the disease progresses, inflammation of the veins and capillaries can occur. Denatured rapeseed oil contains a substance called oleoylanilide. Its major target organ is lung and adipose tissue, and alters fat metabolism in the tissue. Oleanamide also changes the permeability of the cell membrane, releasing arachidonic acid from the phospholipids in the cell membrane. Arachidonic acid is converted to lipid peroxides such as malondialdehyde by the action of cyclooxygenase and can also generate peroxidic free radicals. The authors fed with denatured rapeseed oil rats, and measured liver, lung and kidney tissue MDA and glutathione content, compared with the control group, variable