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目的 探讨肾病综合征 (nephroticsyndrome,NS)患儿维生素D代谢变化。 方法 采集 4 5例NS患儿及 2 0例对照组患儿血、尿标本进行检测 ,定量测血清钙、磷、2 5 (OH)D3 、1,2 5 (OH) 2 D3 浓度及 2 4h尿蛋白。结果 NS患儿血清钙、2 5 (OH)D3 及 1,2 5 (OH) 2 D3 低于对照组 [(1.92± 0 .4 7)mmol/Lvs (2 .2 6± 0 .2 3)mmol/L ,(6 .0 8± 9.15 )ng/mlvs (43.12± 15 .0 4 )ng/ml,(13.0 0± 6 .2 9) pg/mlvs (2 3.78± 11.16 ) pg/ml](P <0 .0 1) ,差异有显著意义 ;而血清磷与对照组相比 [(1.84± 0 .6 7)mmol/Lvs (1.87± 0 .87)mmol/L],无统计学意义 (P >0 .0 5 )。NS患儿血清 2 5 (OH)D3 水平与 2 4h尿蛋白呈负相关关系 (r =- 0 .5 6 3,P <0 .0 5 ) ,血清 1,2 5 (OH) 2 D3水平与 2 4h尿蛋白呈明显负相关 (r =- 0 .6 96 ,P <0 .0 1)。结论 肾病极期体内存在维生素D代谢紊乱 ,其为骨代谢异常的重要原因
Objective To investigate the changes of vitamin D metabolism in children with nephrotic syndrome (NS). Methods Serum levels of calcium and phosphorus, 25 (OH) D3, 1,25 (OH) 2 D3 were measured in 24 children with NS and 20 controls. Urine protein. Results Serum calcium, 25 (OH) D3 and 1,25 (OH) 2 D3 in children with NS were significantly lower than those in control group [(1.92 ± 0.47 mmol / L vs (22.6 ± 0.23) mmol / L, (6.08 ± 9.15) ng / ml vs (43.12 ± 15.0 ± 0.4) ng / ml, (13.0 ± 6.29) pg / ml vs P <0.01), but there was no significant difference between the two groups (P> 0.05). Compared with the control group, serum phosphorus level was significantly higher than that of the control group [(1.84 ± 0.67) mmol / L vs (1.87 ± 0.87) mmol / L] P> 0 .0 5). The level of serum 25 (OH) D3 was negatively correlated with 24 h urinary protein in children with NS (r = - 0.563, P <0.05) 24 h urinary protein was negatively correlated (r = - 0.96 6, P <0.01). Conclusion Vitamin D metabolic disorder is present in the body during the most severe stage of kidney disease, which is an important cause of abnormal bone metabolism