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实验性动脉粥样硬化模型的建立,对开展冠心病的研究具有重要意义。本实验用含2％的胆固醇饲草喂养纯种新西兰家兔,记录动物体重、胆固醇摄入量,采用自身对比的方法观察用药前、中、后血脂浓度总胆固醇CT,游离胆固醇FCH,甘油三脂TG及高密度脂蛋白胆固醇HDL-C)的变化及主动脉粥样斑块形成的情况,探讨血脂与动脉粥样硬化形成的关系,探索建立动脉硬化动物模型的经验,为临床防治冠心病的研究提供条件。
The establishment of experimental atherosclerosis model is of great significance for the study of coronary heart disease. In this experiment, purebred New Zealand rabbits were fed with 2% cholesterol forage to record body weight and cholesterol intake of animals. The levels of total cholesterol (CT), free cholesterol (FCH), triglyceride Lipid TG and high-density lipoprotein cholesterol HDL-C) changes and the formation of aortic atherosclerotic plaque, to explore the relationship between blood lipids and atherosclerosis, to explore the establishment of animal models of atherosclerosis experience for the clinical prevention and treatment of coronary heart disease The research provides the conditions.