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选择血清血栓素(TXB_2)和组织Even蓝岔量为指标,观察大鼠右半结肠缺血再灌注损伤及5-氨基水杨酸(5-ASA)的治疗作用。结果显示,缺血再灌注后结肠组织Even蓝含量及血清中TXB_2的浓度明显增高。结肠内灌注5-ASA后,Even蓝含量和TXB_2浓度下降,以30mg/kg的剂量最明显。以上结果提示,足够剂量的5-ASA有防治结肠缺血再灌注损伤的作用。其作用机理同5-ASA减少氧自由基形成有关。
The levels of TXB_2 and Even Lancha check were used as indicators to observe the therapeutic effects of 5-aminosalicylic acid (5-ASA) on the right colon ischemia-reperfusion injury in rats. The results showed that Even blue content of colon tissue and concentration of TXB_2 in serum increased significantly after ischemia-reperfusion. After the colon was infused with 5-ASA, Even blue content and TXB 2 concentration decreased, the most obvious dose of 30mg / kg. The above results suggest that adequate doses of 5-ASA have the effect of preventing colon ischemia-reperfusion injury. Its mechanism of action and 5-ASA reduce the formation of oxygen free radicals.