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目的：探讨静脉滴注大剂量丙种球蛋白（ＩＶＩＧ）治疗小儿反复呼吸道感染的治疗效果。方法：对２６例患儿以５００ｍｇ／ｋｇ静脉滴注ＩＶＩＧ，每月１次，连续３月。对照组２０例，按常规治疗，不用免疫制剂及血浆。用单向免疫琼脂扩散法和间接免疫荧光法，分别检测治疗前后患儿血清ＩｇＧ、ＩｇＡ、ＩｇＭ、ＣＤ３、ＣＤ４和ＣＤ８，并临床追踪观察１年。结果：ＩＶＩＧ组总有效率为８８．４％，对照组为５０．５％，差异有显著性。治疗后ＩｇＧ、ＣＤ３、ＣＤ４和ＣＤ４／ＣＤ８明显升高（Ｐ＜０．０１），ＣＤ８降低，而对照组治疗前后各免疫指标无明显差异。结论：静脉滴注大剂量ＩＶＩＧ能提高ＲＲＴＩ患儿体液和细胞免疫水平，减少发病次数，是治疗ＲＲＴＩ一种有效方法
Objective: To investigate the therapeutic effect of intravenous infusion of high dose gamma globulin (IVIG) on children with recurrent respiratory tract infections. Methods: 26 infants were infused intravenously with 500 mg / kg IVIG once a month for 3 months. Control group of 20 patients, according to conventional treatment, without immunosuppressive agents and plasma. The serum IgG, IgA, IgM, CD3, CD4 and CD8 in children before and after treatment were detected by one-way immunogold agar diffusion and indirect immunofluorescence, and the clinical follow-up was observed for 1 year. Results: The total effective rate was 88.4% in IVIG group and 50.5% in control group, the difference was significant. After treatment, IgG, CD3, CD4 and CD4 / CD8 were significantly increased (P <0.01), CD8 decreased, while the control group before and after treatment of immune indicators no significant difference. Conclusion: Intravenous infusion of high-dose IVIG can improve the level of humoral and cellular immunity and reduce the incidence of RRTI in children with RRTI, which is an effective method for the treatment of RRTI