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随着分子生物学技术的不断发展,近年来在肿瘤标志物方面的研究相当活跃。在临床已被广泛应用于肿瘤的诊断、评估疗效、监测复发和推测预后。CA125是一种肿瘤相关抗原,正常细胞上少量存在,在癌变过程中CA125含量明显增加。本文就此标志物的生物学特性及其与妇科肿瘤的关系作一综述。1 CA125的生物学特性1981年Bast等首先报道从一名患者的卵巢浆液性乳头状囊腺癌获得上皮细胞株OVCA433,给家鼠作免疫接种,通
With the continuous development of molecular biology techniques, the research on tumor markers has been quite active in recent years. Has been widely used in clinical diagnosis of cancer, assess the efficacy of monitoring recurrence and prognosis. CA125 is a tumor-associated antigen, a small amount of normal cells exist, in the process of carcinogenesis CA125 increased significantly. In this paper, the biological characteristics of this marker and its relationship with gynecological tumors are reviewed. 1 Biological characteristics of CA125 In 1981, Bast et al first reported from a patient with ovarian serous papillary cystadenocarcinoma epithelial cell line OVCA433 obtained for immunization of mice, through