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目的:观察解毒扶正汤治疗胃癌术后化疗致骨髓抑制的临床效果。方法:选择60例胃癌术后化疗患者为研究对象,随机分为对照组和治疗组,每组30例,对照组采用FOLFOX 4化疗方案治疗,治疗组采用FOLFOX 4化疗方案结合解毒扶正汤辅助治疗。比较两组患者临床症状、生活质量、外周血象变化、骨髓抑制程度、重组人粒细胞集落刺激因子(G-CSF)使用等情况。结果:治疗组在临床症状改善程度、生活质量改善情况、外周血白细胞、血小板提高、骨髓抑制程度减轻情况及重组人粒细胞集落刺激因子(G-CSF)使用情况均优于对照组。结论:解毒扶正汤治疗胃癌术后化疗致骨髓抑制有显著疗效,可减轻临床副反应,保证胃癌化疗的顺利进行,提高患者免疫功能及生活质量。
Objective: To observe the clinical effects of Jiedu Fuzheng Decoction in the treatment of postoperative chemotherapy-induced myelosuppression in gastric cancer. Methods: Sixty patients with postoperative chemotherapy for gastric cancer were selected as study subjects and randomly divided into control group and treatment group, 30 cases in each group. The control group was treated with FOLFOX 4 chemotherapy. The treatment group was treated with FOLFOX 4 chemotherapy combined with Jiedu Fuzheng Decoction . Clinical symptoms, quality of life, peripheral blood changes, bone marrow suppression, and the use of recombinant human granulocyte-colony stimulating factor (G-CSF) were compared between the two groups. Results: In the treatment group, the improvement of clinical symptoms, the quality of life, the increase of peripheral blood leukocytes and platelets, the reduction of myelosuppression and the use of recombinant human granulocyte colony-stimulating factor (G-CSF) were all better than the control group. Conclusion: Jiedu Fuzheng Decoction in the treatment of postoperative gastric cancer chemotherapy has a significant effect on bone marrow suppression, clinical side effects can be reduced to ensure the smooth progress of gastric cancer chemotherapy to improve patient immune function and quality of life.