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目的 通过分析比较犬吸入性肺部损伤的CT表现和病理结果 ,为探讨部分液体通气(PLV)治疗吸入性损伤的机理提供实验依据。方法 选用 14条杂种犬 ,采用蒸气吸入造成急性呼吸道损伤后将其分为单纯高频通气对照组与氟碳 (PFC)部分液体通气 +高频通气治疗组。分别对治疗组和对照组犬进行肺部CT扫描 ,同时观察对照组与治疗组的组织病理学变化 ,并将CT和病理结果进行分析、比较。结果 CT表现为斑片状、团絮样模糊的渗出性病灶者 6条犬 ,散在性、点片状渗出灶者 2条犬 ,淡薄、斑片状的磨玻璃样改变者 2条犬 ,部分肺实变者 4条犬 ;PFC在吸入性损伤犬的肺部呈斑块状者 5条犬 ,团絮状者 2条犬 ,弥散者 1条犬 ,其分布也以肺的背侧为主 ,与病理结果一致。结论 PFC液体通气在犬的吸入性肺损伤的分布主要集中在肺的重力依赖区 ,而气体更多地分布在肺的非依赖区 ,与肺的损伤部位一致 ,利于吸入性损伤的治疗。
Objective To analyze and compare the CT manifestations and pathological findings of canine aspiration lung injury in order to provide experimental evidence for investigating the mechanism of partial liquid ventilation (PLV) in treating inhalation injury. Methods Fourteen mongrel dogs were selected and were divided into two groups: high frequency ventilation control group and partial liquid ventilation of fluorocarbon (PFC) + high frequency ventilation group after vapor inhalation caused acute respiratory tract injury. The lungs of the treatment group and the control group were respectively scanned by CT, the histopathological changes of the control group and the treatment group were observed, and CT and pathological results were analyzed and compared. Results CT showed patchy swollen blurry exudative lesions were 6 dogs, scattered, flaky exudate two dogs, light, patchy ground-glass-like changes in two dogs , Part of pulmonary consolidation in 4 dogs; PFC inhalation injury in dogs showed a patchy lungs were 5 dogs, flocks were 2 dogs, diffuse a dog, which also distributed to the back of the lung Mainly consistent with the pathological findings. Conclusions The distribution of PFC fluid in dogs with inhalation lung injury is mainly concentrated in the gravity-dependent area of the lungs, while the gas is more distributed in the lung-independent area and consistent with the lung injury site, which is conducive to the treatment of inhalation injury.