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目的探讨睡眠时间和2型糖尿病(T2DM)的关系,为降低和预防罹患T2DM行为危险因素提供依据。方法选取2013年徐州市慢病基线调查时首次确诊的771例T2DM患者(病例组)为研究对象,排除其他类型糖尿病、神经系统相关疾病及现患其他内分泌系统疾病、心肝肾功能不全、呼吸衰竭、恶性肿瘤等严重疾病者。对照组为无T2DM者,排除标准同病例组。匹配条件按年龄(相差不超过3岁)、性别、居住地、T2DM家族史4个方面,采用1∶1匹配的病例对照研究方法进行匹配。一般人口学情况、生活行为、疾病史和体格检查采用自行设计的调查表,睡眠时间通过研究对象自报告的模式进行调查。采用t检验、χ2检验和多元条件logistic回归进行统计学分析。结果病例组睡眠时间<6 h比睡眠时间6~8 h者患糖尿病的风险增加3.29倍(OR=4.29,95%CI:2.67~6.88),调整入睡时间、睡眠质量、高血压病史、冠心病史、体质指数(BMI)、腰围和生活紧张度等混杂因素后,风险增加1.04倍(OR=2.04,95%CI:1.70~3.86)。睡眠时间>8 h者与6~8 h者差异均无统计学意义(P>0.05)。按性别分层,男性睡眠时间<6 h者患糖尿病的风险增加3.97倍(OR=4.97,95%CI:1.81~13.63),女性睡眠时间<6 h者与T2DM无关联。结论睡眠时间不足使T2DM发生的风险增加,长期睡眠不足者应使生活规律化,按时作息,对T2DM的预防起着积极作用。女性睡眠时间与T2DM的发生风险未发现存在关联。
Objective To explore the relationship between sleep time and type 2 diabetes mellitus (T2DM), and to provide basis for reducing and preventing the risk factors of T2DM. Methods A total of 771 T2DM patients (case group) diagnosed at the baseline survey of chronic diseases in Xuzhou City in 2013 were selected as research objects to exclude other types of diabetes, neurological related diseases and other endocrine system diseases, heart, liver and kidney dysfunction, respiratory Failure, cancer and other serious diseases. The control group without T2DM, excluding the same criteria with the case group. Matching conditions by age (no difference of more than 3 years old), gender, place of residence, family history of T2DM 4 aspects, using a 1: 1 matching case-control study method to match. General demographic information, living behavior, medical history and physical examination using a self-designed questionnaire, sleep time self-reported by the research object to investigate. The t test, χ2 test and multivariate logistic regression were used for statistical analysis. Results The risk of developing diabetes was 3.29 times (OR = 4.29, 95% CI: 2.67-6.88), and the time to sleep, sleep quality, history of hypertension, coronary heart disease Risk increased 1.04-fold (OR = 2.04, 95% CI: 1.70 to 3.86) after confounding factors such as history, body mass index (BMI), waist circumference and life stress. There was no significant difference in sleep time> 8 h and 6 ~ 8 h (P> 0.05). Stratified by sex, the risk of developing diabetes was <3.96 times (OR = 4.97, 95% CI: 1.81 to 13.63) in men who slept for less than 6 hours and was unrelated to T2DM in women who slept <6 hours. Conclusions Insufficient sleep time may increase the risk of T2DM. Long-term sleep deprivation should lead to regular and daily life, which plays an active role in the prevention of T2DM. There was no association between female sleep time and the risk of T2DM.