人乳中脂代谢调控因子的发现,功能和临床意义

• 作 者: 蒋雪 李晓南
• 机 构: 南京医科大学附属南京儿童医院,
• 出 处: 中国儿童保健杂志
• 发表日期: 2013年05期
• 关键词: 婴儿期 脂代谢 生长发育 母乳喂养 成年期肥胖 乳中 人乳 成年期疾病 不饱和脂肪酸 代谢综合征

研究表明,生命早期的营养和生长可能通过“编程”影响生命后期的代谢。母乳喂养能预防婴儿期乃至成年期肥胖、血糖血脂异常等代谢综合征的发生。这不仅与母乳中的蛋白质、不饱和脂肪酸等含量相关,母乳中新发现的一些代谢调控因子如脂联素、肥胖抑制素、微小核酸、乳脂肪球膜、细胞因子等,亦可能直接或间接调节婴儿的代谢及生长发育。认识这些活性物质的生理作用,有助于促进母乳喂养和成年期疾病的早期预防,也为今后婴儿配方奶粉的改进提供重要的科学依据。

Research shows that nutrition and growth in early life may affect metabolism late in life through “programming.” Breastfeeding can prevent infants and adulthood obesity, blood glucose dyslipidemia and other metabolic syndrome. This is not only related to the content of breast milk protein, unsaturated fatty acids and other content of breast milk found in some metabolic regulators such as adiponectin, obesity inhibin, micro nucleic acid, milk fat globule membrane, cytokines, may also be directly or indirectly Regulate baby’s metabolism and growth. Understanding the physiological role of these active substances helps to promote breast-feeding and early prevention of adult diseases, and also provides an important scientific basis for the future improvement of infant formula.