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肿瘤的间质反应在一定程度上反映了宿主抗肿瘤的免疫状态,并和预后有关。非Hodgkin淋巴瘤(NHL)的分类和预后亦涉及肿瘤的间质反应。如Rappaport即根据间质内纤维组织间隔的形状,将NHL分为弥漫型和结节型。本文作者在对中国和澳大利亚NHL患者所做的免疫组织化学比较研究中发现,两国患者间存在着病理形态学上的差异。中国组以弥漫型、小裂核细胞和大细胞(裂-无裂)的混合型以及组织细胞性为主,且胞浆内免疫球蛋白(cIg)的检出率较低;澳大利亚组则以结节型居多;瘤细胞内重链和轻链免疫球蛋白(Ig)的分布比例在
Interstitial tumor response to a certain extent, reflects the immune status of the host anti-tumor, and the prognosis. The classification and prognosis of non-Hodgkin’s lymphoma (NHL) are also involved in interstitial tumor response. For example, Rappaport classifies NHL into diffuse and nodular based on the shape of interstitial interstitial fibroids. The authors compared immunohistochemistry in patients with NHL in China and Australia and found that there are pathological differences between patients in both countries. The Chinese group was dominated by a combination of diffuse, small-fissile, and large-sized cells (split-uncracked), with a low detection rate of intracellular cIg. In Australia, Most of nodules; tumor cells within the distribution of heavy chain and light chain immunoglobulin (Ig) in