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本实验通过测定缺氧和高二氧化碳单独及混合作用后小鼠学习能力的改变,并观察了轻中度缺氧时通过高二氧化碳进一步增加脑血流后小鼠大脑功能的变化情况。结果表明:单独缺氧时,当氧浓度下降到1.83×10~5mg/m~3以下急性暴露后小鼠学习能力下降;而浓度为0.68～1.35×10~5mg/m~3的单纯高二氧化碳急性暴露2小时后小鼠学习能力无明显变改;轻中度缺氧(2.31～1.68×10~5mg/m~3)伴高二氧化碳(0.92±0.03×10~5mg/m~3)后小鼠学习能力与单纯轻中度缺氧相比亦无显著差异。说明轻中度缺氧伴高二氧化碳,并不明显改变单纯轻中度缺氧对小鼠学习能力的影响。由此推测,高二氧化碳所引起的脑血流增加至少不会改善单纯轻中度缺氧对小鼠脑功能的影响。
In this study, we measured the changes of learning ability of mice after hypoxia and high carbon dioxide alone and in combination, and observed the changes of brain function in mice after cerebral blood flow was further increased by high carbon dioxide during mild to moderate hypoxia. The results showed that when the oxygen concentration dropped to 1.83 × 10 ~ 5 mg / m ~ 3, the learning ability of the mice decreased after exposure to oxygen alone. However, the concentration of 0.50 ~ 1.35 × 10 ~ 5 mg / m ~ After 2 hours of acute exposure, there was no significant change in learning ability of mice. After mild hypoxia (2.31 ~ 1.68 × 10 ~ 5mg / m ~ 3) with high carbon dioxide (0.92 ± 0.03 × 10 ~ 5mg / m ~ 3) There was no significant difference in learning ability between rats and simple hypoxia. Mild hypoxia with high carbon dioxide does not significantly affect the learning ability of mice with mild to moderate hypoxia. From this, it is speculated that high carbon dioxide-induced increases in cerebral blood flow will not at least improve the mild-moderate hypoxia on brain function in mice.