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百日咳的人攻击模型微生物病原体攻击人体的研究为研究其感染的自然过程和免疫应答提供了机会,使我们对细菌与病毒病原体以及对感染的免疫应答有了重大认识。以前人体攻击模型用于病毒和细菌病原体的经验评述及有关的伦理考虑可在别处查阅。人体攻击模型用于如下疾病是安全的符合伦理的:对健康人体是非致命的且是自限的疾病;有其能使受试者迅速恢复健康的营救性治疗的疾病。这些研究特别有用,因为能在控制的环境中实施,用少量的志愿者就能
Pertussis Attack Models Microbial Pathogens The attack on humans provides an opportunity to study the natural processes and immune responses of their infections, giving us a great understanding of bacterial and viral pathogens as well as the immune response to infection. Previous empirical reviews of human attack models for viral and bacterial pathogens and related ethical considerations can be consulted elsewhere. The human attack model is safe and ethical in that it is a non-fatal and self-limiting disease in healthy humans and has a disease that enables subjects to rapidly recover a healthy rescue treatment. These studies are particularly useful because they can be implemented in a controlled environment with a small number of volunteers