【摘 要】
：
The present study was designed to synthesize 2-Cyano-3,12-dioxooleana-1,9(11)-en-28-oate-13β,28-olide (1),a lactone derivative of oleanolic acid (OA) and evaluate its anti-inflammatory activity.Compound 1 significantly diminished nitric oxide (NO) product
【机 构】
：
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery, for Metabolic D
论文部分内容阅读
The present study was designed to synthesize 2-Cyano-3,12-dioxooleana-1,9(11)-en-28-oate-13β,28-olide (1),a lactone derivative of oleanolic acid (OA) and evaluate its anti-inflammatory activity.Compound 1 significantly diminished nitric oxide (NO) production and down-regulated the mRNA expression of iNOS,COX-2,IL-6,IL-1β,and TNF-α in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.Further in vivo studies in murine model of LPS-induced acute lung injury (ALI) showed that 1 possessed more potent protective effects than the well-known anti-inflammatory drug dexamethasone by inhibiting myeloperoxidase (MPO) activity,reducing total cells and neutrophils,and suppressing inflammatory cytokines expression,and thus ameliorating the histopathological conditions of the injured lung tissue.In conclusion,compound 1 could be developed as a promising anti-inflammatory agent for intervention of LPS-induced ALI.
其他文献
The inducible co-activator PGC-1a plays a crucial role in adaptive thermogenesis and increases energy expenditure in brown adipose tissue (BAT).Meanwhile,chronic inflammation caused by infiltrated-macrophage in the white adipose tissue (WAT) is a target f
Si-Miao-Wan (SMW),a tradiational Chinese medicinal formula consisting of Atractylodis Rhizoma,Phellodendri Chinensis Cortex,Coicis Semen,and Achyranthis Bidentatae Radix,has been used for the treatment of gout and gouty arthritis for many years.In the pre
The present study was designed to determine the chemical constituents of the stem tuber ofPinellia pedatisecta.The chemical constituents were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of
The present study was designed to develop a sensitive and selective specific high performance liquid chromatography (HPLC)-tandem mass spectrometric method (MS/MS) for the determination of ligupurpurosides B and C in rat plasma.The samples were prepared a
Three new alkyl substituted anthraquinone derivatives,trivially named as symploquinones A-C (Compounds 1-3) were isolated from Symplocos racemosa.The structures of these compounds were determined on the basis of extensive spectroscopic analyses (UV,IR,Mas