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目的 :应用新生儿行为神经测定观察高压氧治疗新生儿缺氧缺血性脑病 (HIE)的疗效。方法 :对照组 5 0例 ,给常规对症处理 ,营养脑细胞治疗。治疗组 5 0例 ,在常规对症处理、营养脑细胞治疗基础上 ,加用高压氧治疗。高压氧治疗前后行新生儿行为神经测定 (NBNA)。结果 :治疗后治疗组中、重度HIE患儿的NBNA评分分别为 ( 3 7 0 5± 0 80 )、( 3 5 5 0± 1 41) ,对照组分别为( 3 3 3 3± 0 83 )、( 3 1 3 5± 1 83 ) ,差异有显著性意义 (P <0 0 1)。治疗后治疗组NBNA评分异常的患儿 5例 ,对照组NBNA评分异常的患儿 14例 ,两组异常率比较差异有显著性意义 ( χ2 =4 2 1,P <0 0 5 )。结论 :高压氧治疗HIE疗效确切 ,NBNA是评估高压氧治疗中重度HIE疗效的理想方法 ,简便、易行。
Objective: To observe the effect of hyperbaric oxygen therapy on neonatal hypoxic-ischemic encephalopathy (HIE) with neonatal behavioral nerve assay. Methods: The control group 50 cases, to conventional symptomatic treatment, nutrition brain cell therapy. Treatment group 50 cases, in the conventional symptomatic treatment, nutritional brain cells based on the treatment, plus hyperbaric oxygen therapy. Neonatal Behavioral Nerve Determination (NBNA) before and after Hyperbaric Oxygen Therapy. Results: After treatment, the NBNA scores of the children with severe HIE were (3750 ± 0 80) and (3550 ± 1 41) respectively, and those of the control group were (3333 ± 0 83) , (3 1 3 5 ± 1 83) respectively, with significant difference (P <0.01). After treatment, 5 cases of abnormal NBNA score in treatment group and 14 cases of abnormal NBNA score in control group showed significant difference (χ2 = 4221, P <0.05). CONCLUSION: Hyperoxia is effective in treating HIE. NBNA is an ideal method to evaluate the efficacy of Hyperoxia in the treatment of severe HIE. It is simple and easy to perform.