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无机和有机砷化物对机体影响研究较多,但研究所用的方法不能阐明砷代谢的情况。自从Braman使用分别测定体内不同砷化物的方法,使得砷代谢的研究得到了迅速的进展。最初阐明了人尿中的砷有四种形态:无机的三价砷(As~(3+))、五价砷(As~(5+))、及有机的甲胂酸(MAA)、二甲胂酸(DMAA)等。最近又逐步阐明了人口服无机砷后,尿中砷的代谢产物及实验动物经口投与无机砷后,血液、脏器、组织中砷的化学形态。无机砷在尿中的代谢产物:Crecelius(1977)证明人服含砷的酒(As~(3+)50μg·As~(5+)13μg)后,尿砷的大部分为DMAA及MAA。作者自身一次
Inorganic and organic arsenide on the body more research, but the method used in the study can not clarify the situation of arsenic metabolism. Since Braman’s use of separate assays for different arsenic compounds in the body has led to rapid advances in arsenic metabolism research. It was initially clarified that there are four forms of arsenic in human urine: inorganic trivalent arsenic (As 3+), pentavalent arsenic (As 5+) and organic cacodylic acid (MAA) Cacodylic acid (DMAA) and so on. Recently, the chemical forms of arsenic in blood, organs and tissues after oral administration of inorganic arsenic, metabolic products of urinary arsenic and experimental animals after oral administration of inorganic arsenic have been gradually clarified. Metabolites of inorganic arsenic in urine: Crecelius (1977) showed that the majority of urinary arsenic was DMAA and MAA after arsenic-containing wine (As 3+ 50 μg · As 5+ 13 μg) was administered. The author himself