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给Ｗｉｓｔａｒ大鼠孕期分别自由饮用０．６ｍｇ／Ｌ（对照组），２５ｍｇ／Ｌ含氟水，其子鼠（饮用同浓度含氟水）至７５ｄ，探讨胚胎期至生长发育期接触较高剂量氟对雄鼠性腺的影响。检测结果显示，在该染氟剂量和时间内，氟未引起睾丸组织脂质过氧化作用发生改变。但睾丸ＬＤＨ－Ｘ酶活性显著增高，唾液酸含量亦显著升高，血浆ＬＤＨ活性降低。表明氟可引起睾丸组织的生化功能改变．对睾丸组织的细胞有一定损伤作用，旦这种损伤作用似不是通过引起脂质过氧化造成的。
Wistar rats were free to drink during pregnancy 0.6mg / L (control group), 25mg / L fluoride water, its offspring (drinking the same concentration of fluoride-containing water) to 75d to explore the embryonic period to the growth and development of exposure to higher doses Effect of fluoride on male gonads. Test results showed that fluoride did not cause changes in lipid peroxidation of testicular tissue during the dose and time of fluoride exposure. However, testicular LDH-X enzyme activity was significantly increased sialic acid content was significantly increased plasma LDH activity decreased. Fluorine can cause biochemical changes in testis tissue. Testicular tissue cells have a certain role in injury, once this damage does not seem to be caused by lipid peroxidation caused.