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近10年来对IL-2的研究取得了一系列的进展.从其产生,提纯、基因克隆、到它的多种生物活性都有了较深入的了解。并且发现一些疾病与IL-2水平的高低有关.从1984年开始用于临床治疗和诊断细胞免疫缺陷。但由于体内同时存在能降低IL-2生成和活性的物质,因而影响了免疫治疗的效果。目前已知的IL-2抑制因子可分为两大类:一类是PGE_2,1,25双羟维生素D_3等小分子物质,另一类是血清天然的大分子蛋白或多肽。近年来对血清中天然IL-2抑制物的定性以
In the past 10 years, the research on IL-2 has made a series of progress. From its production, purification, gene cloning, to its various biological activities have a deeper understanding. And some diseases have been found to be related to the level of IL-2. Since 1984, they have been used for clinical treatment and diagnosis of cellular immunodeficiency. However, due to the presence of substances that reduce the production and activity of IL-2 in the body, the effect of immunotherapy is affected. The currently known inhibitors of IL-2 can be divided into two major groups: one is a small molecule substance such as PGE2, 1,25-dihydroxyvitamin D3, and the other is a serum natural macromolecular protein or polypeptide. The characterization of natural IL-2 inhibitors in serum in recent years