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目的:分析阿斯匹林不合理停药原因及干预措施。方法:选取2012年1月—2014年9月期间没有医嘱而擅自停止使用阿斯匹林药物的高血压病症患者130例作为研究对象,分析患者的临床资料和不合理停药的原因,并根据患者的不同情况,将患者分为个性化干预组(65例)与一般性干预组(65例);一般性干预组患者仅要求患者参与阿斯匹林药物使用知识讲座活动,个性化干预组患者在一般性干预组的基础上实施定期随访和个性化指导用药,观察患者干预后1月和干预后3月内按时按量服药人数做一对比分析。结果:导致患者不合理停药的原因主要为害怕长期使用药物产生药物不良反应而擅自停药者102例占总数的78.46%,包括用药过程中31例患者出现不良反应,5例患者自认为没有必要服药者占总数的3.85%,另外23例患者为其他原因所致者,占总数的17.69%;干预后两组患者的服药情况发现两组患者在干预后1月服药人数经比较其差异无统计学意义(P>0.05),而在干预后3月,个性化干预组患者按时按量服药例数多于一般性干预组(P<0.05)。结论:导致阿斯匹林不合理停药的原因主要是由于患者的不良认知,对此通过对患者实施定期随访和个性化指导用药可显著改善患者不合理停药现象。
Objective: To analyze the reason and intervention of aspirin unreasonable withdrawal. Methods: One hundred and thirteen patients with hypertensive disorder without aspirin who stopped using aspirin drug from January 2012 to September 2014 were selected as the research object, and the clinical data of the patients and the reason of unreasonable withdrawal were analyzed. Patients were divided into individualized intervention group (65 cases) and general intervention group (65 cases). Patients in general intervention group only required patients to participate in aspirin use of medicine knowledge lecture activity, and individualized intervention group Patients in the general intervention group based on the implementation of regular follow-up and personalized guidance of medication, observation of patients with intervention in January and within 3 months after the intervention on a timely basis the amount of medication to do a comparative analysis. Results: The main reasons leading to unreasonable withdrawal of patients were long-term use of drugs to produce adverse drug reactions and drug-free withdrawal of 102 cases accounted for 78.46% of the total, including medication during the adverse reactions in 31 patients, 5 patients that they did not think The need to take medication accounted for 3.85% of the total, while the other 23 patients were caused by other reasons, accounting for 17.69% of the total; medication intervention two groups of patients found that the two groups of patients in January after intervention compared the difference was (P> 0.05). However, in the three months after the intervention, the patients in the personalized intervention group took more doses on time than the general intervention group (P <0.05). CONCLUSIONS: The causes of aspirin irrational discontinuation are mainly due to the poor cognition of patients. In this regard, regular follow-up and personalized instruction of patients can significantly improve patients’ irrational withdrawal.