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为了了解碱性成纤维细胞生长因子（ｂ－ＦＧＦ）和转化生长因子β１（ＴＧＦ－β１）在人良性前列腺增生症发病中的作用，采用分子杂交技术研究ｂ－ＦＧＦ和ＴＧＦ－β１在人增生前列腺组织中的表达，并观察雄激素水平改变对ｂ－ＦＧＦ及ＴＧＦ－β１表达的影响。２０例行耻骨上经膀胱前列腺摘除术的患者随机分成两组。其中一组术前口服甲地孕酮（１２０ｍｇ／ｄ）及己烯雌酚（２ｍｇ／ｄ）一周。结果：患者的外周血睾酮浓度从服药前的４０６．１±２３１．４μｇ／Ｌ降至服药后１８．０±９．１μｇ／Ｌ（均值±标准差），均达到药物去势水平；未服药组前列腺组织ｂ－ＦＧＦｍＲＮＡ表达水平是服药组的２．０９倍（Ｐ＜０．０１）；服药组前列腺组织ＴＧＦβ１ｍＲＮＡ表达水平是未服药组的１．４９倍（Ｐ＜０．０１）。提示雄激素水平变化可影响ｂ－ＦＧＦ及ＴＧＦ－β１的表达，ｂ－ＦＧＦ及ＴＧＦ－β１异常表达可能参与了人类良性前列腺增生症的发病。
To investigate the role of basic fibroblast growth factor (b-FGF) and transforming growth factor β1 (TGF-β1) in the pathogenesis of human benign prostatic hyperplasia, molecular hybridization was used to study the role of b-FGF and TGF- The expression of b-FGF and TGF-β1 in androgen were observed. Twenty patients undergoing suprapubic transvesical prostatectomy were randomized into two groups. One group of preoperative oral megestrol (120mg / d) and diethylstilbestrol (2mg / d) a week. Results: The testosterone concentration in peripheral blood decreased from 406.1 ± 231.4μg / L before taking to 18.0 ± 9.1μg / L (mean ± standard deviation), all of which reached the level of drug castration; The expression level of b-FGFmRNA in prostate tissue was 2.09 times (P <0.01). The expression of TGF-β1mRNA in prostate tissue was 1.49 times (P <0.01) higher than that in the untreated group. These results suggest that the changes of androgen levels may affect the expression of b-FGF and TGF-β1. The abnormal expressions of b-FGF and TGF-β1 may be involved in the pathogenesis of human benign prostatic hyperplasia.