论文部分内容阅读
目的:通过两组的治疗结果,证实化疗同时应用γ干扰素能有效保护患者的免疫功能。方法:45例胃癌患者中32例获得根治性切除,45例术后均行FHP方案化疗,其中18例同时使用γ干扰素,另选18例作为对照组。两组治疗前后分别抽取外周静脉血测定T细胞亚群(CD系列)变化。结果:统计显示应用FHP+γ干扰素组患者CD3、CD4和NK细胞数量均呈上升,且CD4/CD8比值也升高,与对照组有明显差异。结论:提示γ干扰素作为一种生物免疫制剂不仅能激发和调整机体的免疫功能,而且能与化疗药物互补,增强抗恶性肿瘤治疗的效果。
OBJECTIVE: To verify the efficacy of concurrent use of gamma interferon in protecting the patient’s immune function through the treatment results of the two groups. Methods: Among 45 patients with gastric cancer, radical resection was performed in 32 patients and FHP chemotherapy was performed in 45 patients. 18 patients received IFN-γ at the same time, and 18 patients were selected as control group. Peripheral venous blood was collected before and after treatment to determine changes in T-cell subsets (CD series). Results: The statistics showed that the number of CD3, CD4 and NK cells in patients with FHP + gamma interferon increased, and the ratio of CD4/CD8 also increased, which was significantly different from the control group. Conclusion: It is suggested that IFN-γ as a biological immunization preparation not only stimulates and adjusts the body’s immune function, but also complements the chemotherapeutic agent and enhances the effect of anti-malignant treatment.