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目的探讨盐酸米诺环素软膏和替硝唑局部用药治疗牙周炎的临床疗效差异。方法 139例口腔科住院治疗的牙周炎患者,根据治疗方式不同分为替硝唑组(59例)和米诺环素组(80例),比较两组患者临床治疗效果。结果米诺环素组患者临床治疗有效率86.25%明显高于替硝唑组72.88%(P<0.05),同时米诺环素组患者牙周炎深度(PD)、牙龈出血指数(GBI)、牙龈附着水平(AL)和菌斑指数(PLI)等指标(2.78±0.44)、(0.65±0.10)、(2.25±0.61)、(0.78±0.15)明显优于替硝唑组(3.31±0.50)、(1.75±0.37)、(3.37±0.58)、(1.46±0.22)(P<0.05)。结论与替硝唑局部用药相比,盐酸米诺环素局部用药在治疗牙周炎方面临床效果更佳明显,且可有助于改善患者牙周炎指标,促进病灶早日康复。
Objective To investigate the clinical efficacy of minocycline hydrochloride ointment and topical tinidazole in the treatment of periodontitis. Methods One hundred and ninety-three patients with periodontitis admitted to the dentistry department were divided into two groups: the tinidazole group (n = 59) and the minocycline group (n = 80). The clinical effects of the two groups were compared. Results The effective rate of clinical treatment in minocycline group was 86.25%, which was significantly higher than that of tinidazole group (72.88%, P <0.05). Meanwhile, the patients in the minocycline group had significantly lower PD, GBI, (AL), plaque index (PLI) and other indicators (2.78 ± 0.44), (0.65 ± 0.10), (2.25 ± 0.61) and (0.78 ± 0.15) were significantly better than those of the tinidazole group (3.31 ± 0.50) , (1.75 ± 0.37), (3.37 ± 0.58) and (1.46 ± 0.22) respectively (P <0.05). Conclusion Compared with topical tinidazole, local application of minocycline hydrochloride in the treatment of periodontitis has better clinical effect, and may help to improve the indicators of patients with periodontitis and promote the early recovery of the lesion.