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目的观察大黄治疗急性重度敌敌畏中毒合并乙醇中毒的临床疗效。方法将70例急性重度敌敌畏中毒合并乙醇中毒患者随机分为对照组与治疗组,每组35人,对照组给予常规综合治疗,治疗组在常规治疗基础上,每日给予大黄液100 ml,分2次口服或鼻饲,共用5 d。观察2组患者的病死率、患者从昏迷转为清醒的时间、胆碱酯酶活力上升至正常低限时间、肝功能恢复正常时间、阿托品及氯磷啶用量、住院天数。结果治疗组患者病死率为2.9%,对照组患者病死率为22.9%,2组差异有统计学意义(P<0.05)。治疗组与对照组相比,患者从昏迷转为清醒的时间、胆碱酯酶活力上升至正常低限时间缩短,肝功能恢复加快,阿托品及氯磷啶用量减少,住院时间缩短,2组差异有统计学意义(P<0.05)。结论使用大黄救治急性重度敌敌畏中毒合并乙醇中毒患者具有较好的疗效,值得临床推广使用。
Objective To observe the clinical efficacy of rhubarb in the treatment of acute severe dichlorvos poisoning combined with alcoholism. Methods Seventy patients with acute severe dichlorvos poisoning complicated with alcoholism were randomly divided into control group and treatment group, with 35 in each. The control group was given conventional comprehensive treatment. On the basis of routine treatment, the treatment group was given 100 ml of rhubarb solution daily, 2 times oral or nasal feeding, sharing 5 d. The mortality of patients in two groups was observed. The patients’ time from coma to awake, the activity of cholinesterase increased to the normal low limit, the time of recovery of liver function, the dosage of atropine and chlorophosphon, the days of hospitalization were observed. Results The case fatality rate was 2.9% in the treatment group and 22.9% in the control group. The difference between the two groups was statistically significant (P <0.05). The treatment group compared with the control group, patients from the coma to awake time, cholinesterase activity increased to the normal low limit of time shortened, liver function recovery accelerated, atropine and chlorophosphonates decreased dosage, shorter hospital stay, two groups of differences There was statistical significance (P <0.05). Conclusion The use of rhubarb for the treatment of acute severe dichlorvos poisoning patients with ethanol poisoning has a good effect, worthy of clinical promotion.