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本文报道天津市儿童保健所自1989年7月—1990年9月间用自己制备的~(125)I—TSH纸片法放射免疫试剂盒,对天津市区及郊县29520例新生儿筛查的结果。市区筛查人数22800人,以测定足血TSH为主,复查率0.34％,郊县筛查人数6720人,均测定脐血TSH,复查率1.5％。通过15个月的筛查,共发现患儿4例,按市区(非缺碘地区)和郊县(缺碘地区)分别计算发病率,前者为1/7820,后者为1/2927。文中详细介绍了筛查的程序和存在的问题,并对足血、脐血标本在筛查中的利弊及以TSH或T作为筛查指标的可靠程度进行了讨论。
This paper reports Tianjin Children’s Health Center from July 1989 to September 1990 with their own preparation of ~ (125) I-TSH disk radioactive immunoassay kit, 29,520 newborns in Tianjin urban area and suburban screening result. Urban population of 22,800 people to determine the foot blood TSH-based, the review rate of 0.34%, 6720 counties in the suburbs of screening, were measured cord blood TSH, the review rate of 1.5%. After 15 months of screening, a total of 4 children were found, and the incidence was calculated respectively in urban (non-iodine-deficient areas) and suburban counties (iodine-deficient areas), the former being 1/7820 and the latter being 1/2927. This article describes in detail the screening procedure and existing problems, and discusses the advantages and disadvantages of screening blood samples and umbilical cord blood samples and the reliability of TSH or T screening.