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应用多重ＰＣＲ技术分析了２８例胃癌组织ｐ１６基因第２外显子缺失情况。结果显示，胃癌组织ｐ１６基因第２外显子缺失率达１４．３％（４／２８），且伴有ｐ１６基因缺失的胃癌均有周围器官的转移。提示ｐ１６基因缺失与胃癌发生发展有关，ｐ１６基因缺失患者易发生周围器官转移，预后不良。
Multiplex PCR was used to analyze the absence of exon 2 of p16 gene in 28 cases of gastric cancer. The results showed that the deletion rate of exon 2 of p16 gene in gastric cancer tissue was 14.3% (4/28), and gastric cancer with p16 gene deletion had peripheral organ metastasis. It is suggested that deletion of p16 gene is associated with the occurrence and development of gastric cancer. Patients with deletion of p16 gene are prone to peripheral organ metastasis and have poor prognosis.