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AIM: To evaluate the possibility of treatment effect monitoring using hepatic fat quantification magnetic resonance(MR) in pediatric nonalcoholic steatohepatitis(NASH).METHODS: We retrospectively reviewed the medical records of patients who received educational recommendations and vitamin E for NASH and underwent hepatic fat quantification MR from 2011 to 2013.Hepatic fat fraction(%) was measured using dual- and triple-echo gradient-recalled-echo sequences at 3T.The compliant and non-compliant groups were compared clinically,biochemically,and radiologically.RESULTS: Twenty seven patients(M:F = 24:3; mean age: 12 ± 2.3 years) were included(compliant group = 22,non-compliant = 5).None of the baseline findings differed between the 2 groups,except for triglyceride level(compliant vs non-compliant,167.7 mg/d L vs 74.2 mg/d L,P = 0.001).In the compliant group,high-density lipoprotein increased and all other parameters decreased after 1-year follow-up.However,there were various changes in the non-compliant group.Dualecho fat fraction(-19.2% vs 4.6,P < 0.001),tripleecho fat fraction(-13.4% vs 3.5,P < 0.001),alanine aminotransferase(-110.7 IU/L vs-10.6 IU/L,P = 0.047),total cholesterol(-18.1 mg/d L vs 3.8 mg/d L,P = 0.016),and triglyceride levels(-61.3 mg/d L vs 11.2 mg/d L,P = 0.013) were significantly decreased only in the compliant group.The change in body mass index and dual-echo fat fraction showed a positive correlation(ρ = 0.418,P = 0.030).CONCLUSION: Hepatic fat quantification MR can be a non-invasive,quantitative and useful tool for monitoring treatment effects in pediatric NASH.
AIM: To evaluate the possibility of treatment effect monitoring using hepatic fat quantification magnetic resonance (MR) in pediatric nonalcoholic steatohepatitis (NASH). METHODS: We retrospectively reviewed the medical records of patients who received educational recommendations and vitamin E for NASH and underwent hepatic fat quantification MR from 2011 to 2013. Hepatic fat fraction (%) was measured using dual- and triple-echo gradient-recalled-echo sequences at 3T. compliant and non-compliant groups were more clinically, biochemically, and radiologically .RESULTS: Twenty Seven patients (M: F = 24: 3; mean age: 12 ± 2.3 years) were included (compliant group = 22, non-compliant = 5) .None of the baseline findings differed between the 2 groups, except for triglyceride level compliant vs non-compliant, 167.7 mg / d L vs 74.2 mg / d L, P = 0.001) .In the compliant group, high-density lipoprotein increased and all other parameters decreased after 1-year follow-up.However, there were various changes in th triple-fat fraction (-13.4% vs 3.5, P <0.001), alanine aminotransferase (-110.7 IU / L vs-10.6 IU / L (P = 0.047), total cholesterol (-18.1 mg / d L vs 3.8 mg / d L, P = 0.016), and triglyceride levels (-61.3 mg / d L vs 11.2 mg / d L, decreased only in the compliant group. change in body mass index and dual-echo fat fraction showed a positive correlation (ρ = 0.418, P = 0.030) .CONCLUSION: Hepatic fat quantification MR can be non-invasive, quantitative and useful tool for monitoring treatment effects in pediatric NASH.