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目的 :研究神经梅毒治疗后快速血浆反应素试验(rapid plasma reagin test,RPR)滴度变化替代脑脊液检测预测疗效的可行性。方法:治疗47例符合条件的神经梅毒患者后,记录6个月的血清RPR滴度及脑脊液异常,并分析治疗前不同血清RPR滴度下有效预测值的差异。结果 :治疗后6个月,26例(55.3%)患者血清RPR治疗有效,37例(78.7%)患者脑脊液异常治疗有效,治疗前血清RPR≥1∶16的患者组血清RPR滴度变化更能预测脑脊液异常的变化。结论:在高血清滴度的患者中,血清RPR可以替代脑脊液检查预测神经梅毒患者的疗效,避免过多腰椎穿刺检查。
Objective: To study the feasibility of predicting the curative effect of cerebrospinal fluid (CSF) by rapid plasma reagin test (RPR) titer after neurosyphilis treatment. Methods: Serum RPR titers and cerebrospinal fluid abnormalities were recorded after 47 patients with neurosyphilis who met the criteria. The differences in the effective predictive values of serum RPR titers before treatment were analyzed. RESULTS: Six months after treatment, serum RPR was effective in 26 patients (55.3%). Cerebrospinal fluid abnormalities were effective in 37 patients (78.7%). Serum RPR titers in patients with pre-treatment serum RPR≥1: 16 were more variable Predict changes in cerebrospinal fluid abnormalities. CONCLUSIONS: Serum RPR may be an alternative to cerebrospinal fluid in predicting the efficacy of neurosyphilis in patients with high serum titers and avoids excessive lumbar puncture.