Maintaining proton homeostasis is an essential role of the Warburg effect in proliferating cells

• 作 者: Chuangzhen Yang Binghui Li
• 机 构: DepartmentofBiochemistryandMolecularBiology,AdvancedInnovationCenterforHumanBrainProtection,BeijingK
• 出 处: 癌症生物学与医学:英文版
• 发表日期: 2019年3期
• 关键词: Maintaining PROTON HOMEOSTASIS WARBURG effect PROLIFERATING CELLS
• 基金项目: supported by National Natural Science Foundation of China(Grant No.81622037 and 81672762),Beijing Municipal Natural Science Foundation(Grant No.5194023),Support Project of High-level Teachers in Beiji

Non-proliferating cells efficiently generate adenosine 5’-triphosphate (ATP) through mitochondrial oxidative phosphorylation.By contrast, proliferating cells, including cancer cells, tend to rely on aerobic glycolysis, an inefficient way to generate energ