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目的探讨术后放疗对T1和T2期伴有1~3个腋窝淋巴结转移不同年龄组乳腺癌患者的影响及其预后因素分析。方法研究对象为2005年1月至2010年9月经手术证实的伴有1~3个腋窝淋巴结转移的T1或T2期231例乳腺癌患者,所有患者均行乳腺癌改良根治术。采用Kaplan-Meier法计算总生存率(OS)、局控率(LC)、无病生存率(DFS),行卡方检验。结果全组患者3年的OS、LC和DFS分别为95.5%、95.0%、89.4%。结论术后放疗可以提高T1和T2期伴有1~3个腋窝淋巴结转移的乳腺癌患者OS、LC、DFS。低年龄组受益更明显。
Objective To investigate the effect of postoperative radiotherapy on breast cancer patients with different ages in T1 and T2 with 1-3 axillary lymph node metastases and its prognostic factors. Methods Totally 231 breast cancer patients with stage T1 or T2 with 1 ~ 3 axillary lymph node metastasis confirmed by surgery from January 2005 to September 2010 were enrolled. All patients underwent modified radical mastectomy. Kaplan-Meier method was used to calculate the overall survival rate (OS), local control rate (LC), disease-free survival (DFS), line chi-square test. Results The three-year OS, LC and DFS of the three groups were 95.5%, 95.0% and 89.4% respectively. Conclusion Postoperative radiotherapy can improve OS, LC and DFS in T1 and T2 breast cancer patients with 1 to 3 axillary lymph node metastases. Lower age group benefit more obvious.