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本文报道了用1％二乙烯苯交联的聚苯乙烯基磺酰氯树脂支载的5′-O-单-P-甲氧基-2′-脱氧-3′-磺酸酯胸苷在甲醇钠作用下进行酯的α,β-消除反应制备了较高产率的5′-O-单-P-甲氧基三苯甲基-2′,3′-双脱氧胸苷。
This paper reports the use of polystyrene sulfonyl chloride resin-supported 5’-O-monomethoxy-2’-deoxy-3’-sulfonate thymidine crosslinked with 1% divinylbenzene in methanol The high yield of 5’-O-mono-P-methoxytrityl-2 ’, 3’-dideoxythymidine was prepared by the esterification of α, β-elimination reaction with sodium.