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目的探讨瑞舒伐他汀对老年冠心病伴高脂血症患者血脂及高敏C反应蛋白的影响。方法采用对照研究的方法,将72例患者随机分为治疗组(36例)和对照组(36例),治疗组服用瑞舒伐他汀钙片10 mg/d。观察治疗前后的血脂(TC、TG、LDL-C、HDL-C)及hs-CRP。结果治疗组治疗后较治疗前的TC、TG、LDL-C、hs-CRP明显下降,HDL-C升高(P<0.05)。治疗组治疗后较对照组治疗后的TC、TG、LDL-C、hs-CRP明显下降,HDL-C升高(P<0.05)。对照组治疗前后的血脂各指标及hs-CRP比较,差异无统计学意义(P>0.05)。结论瑞舒伐他汀可以使老年冠心病伴高脂血症患者的TC、TG、LDL-C、hs-CRP下降,HDL-C升高。
Objective To investigate the effect of rosuvastatin on serum lipids and high-sensitivity C-reactive protein in elderly patients with coronary heart disease and hyperlipidemia. Methods 72 patients were randomly divided into treatment group (36 cases) and control group (36 cases). The treatment group received rosuvastatin calcium 10 mg / d. Blood lipid (TC, TG, LDL-C, HDL-C) and hs-CRP before and after treatment were observed. Results After treatment, TC, TG, LDL-C and hs-CRP in the treatment group decreased significantly and HDL-C increased (P <0.05). After treatment, TC, TG, LDL-C, hs-CRP and HDL-C in the treatment group were significantly lower than those in the control group (P <0.05). There was no significant difference in the indexes of serum lipid and hs-CRP before and after treatment in the control group (P> 0.05). Conclusion Rosuvastatin can reduce the levels of TC, TG, LDL-C, hs-CRP and HDL-C in elderly patients with coronary heart disease and hyperlipidemia.