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马拉硫磷是一种广泛应用的有机磷农药,但对马拉硫磷的遗传作用了解不多,作者对31例急性农药中毒的患者进行了研究。其中有半数人均不同程度地接触过马拉硫磷。对这些人淋巴细胞的检查表明:在接触的当时和一个月后都看到染色体断裂以及稳定的和不稳定的染色体畸变显著增加,但没有剂量-效应关系,并且也不能确定所接触的准确浓度。马拉硫磷对细菌不诱变。中国地鼠细胞与浓度为50～400μg/ml 的马拉硫磷体外接触未见到染色体断裂数增加;只表明有细胞毒性作用。因为化学物诱导姊妹染色单体互换(SCE)
Malathion is a widely used organophosphorus pesticide, but little is known about the genetic role of malathion. The authors studied 31 patients with acute pesticide poisoning. Half of them were exposed to malathion to varying degrees. Examination of these human lymphocytes revealed a significant increase in chromosome breakage and stable and unstable chromosomal aberrations both at the time of the one and one month after exposure, but without a dose-response relationship, nor was it possible to determine the exact concentration . Malathion is not mutagenic to bacteria. Chinese hamster cells and the concentration of 50 ~ 400μg / ml of malathion in vitro contact with no increase in the number of chromosome breaks; only showed cytotoxicity. Because chemicals induce sister chromatid exchange (SCE)