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用放免法测定106例心脏病患者及30例正常人的血浆免疫活性精氨酸加压素(ir-AVP)含量,发现心功能Ⅱ级以上患者血浆ir-AVP水平明显高于正常对照组(P<0.05);合并房颤者的ir-AVP低于无房颤者(P<0.01);低钠血症患者的ir-AVP则高于正常血钠者(P<0.01)。相关分析显示患者组血浆ir-AVP与血浆渗透压无关,而与血管紧张素Ⅱ含量有弱相关(r=0.256,P<0.01)。结果提示心力衰竭时不适当的AVP分泌增多与稀释性低钠血症有关。
The radioimmunoassay of ir-AVP in 106 patients with cardiac disease and 30 healthy controls by radioimmunoassay showed that the level of ir-AVP in patients with cardiac function gradeⅡwas significantly higher than that in the normal control group (P <0.05). The ir-AVP in patients with atrial fibrillation was lower than those without atrial fibrillation (P <0.01). The level of ir-AVP in patients with hyponatremia was higher than that in patients with normal sodium (P <0.01). Correlation analysis showed that plasma ir-AVP was not related to plasma osmolality but weakly correlated with angiotensin II (r = 0.256, P <0.01). The results suggest that inadequate AVP secretion during heart failure is associated with dilutional hyponatremia.