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成人获得乙型肝炎病毒(HBV)感染后,95%自发清除;而>90%新生儿和1-5岁儿童约30%感染肝炎病毒后却无法清除,并发展成慢性感染。近日台湾大学的一群学者们解释肠道菌群或与这种年龄相关的肝炎发作有一定关系。这篇研究发表在最新一期的PNAS上。人类和驻留在我们的身体里的细菌处于共生关系。这些细菌和它们各自的环境被称为微生物。生活在肠道里的微生物一直特别令人感兴趣,因为最近的研究表明肠道菌群的组成与能影响免疫系统的某些疾病之间有相关性。研究人员发现成年小鼠都表现出清除病毒的能力,而年轻小鼠却没有。12周大的成年小鼠感染HBV后,5周后病毒清除。而年轻的小鼠感染
Ninety-five percent of adults spontaneously remove hepatitis B virus (HBV) infection, and about 30% of newborns and 1-5 year-old children are not cleared of hepatitis B virus and develop chronic infection. Recently, a group of scholars at Taiwan’s University explained that there is a certain relationship between gut flora and the onset of such age-related hepatitis. This research is published in the latest issue of PNAS. Humans live in symbiosis with the bacteria that reside in our bodies. These bacteria and their respective environments are called microbes. Microbes living in the intestine have been of particular interest as recent studies have shown that there is a correlation between the composition of the gut flora and certain diseases that affect the immune system. The researchers found that adult mice showed the ability to clear the virus, but young mice did not. After 12 weeks old adult mice were infected with HBV, the virus was cleared 5 weeks later. While young mice are infected