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目的了解产前诊断胎儿缺陷终止妊娠病例特征,探索早期发现与干预模式。方法选取嘉兴市妇幼保健院2012年10月—2014年9月产前诊断胎儿严重缺陷终止妊娠601例,分析孕妇年龄、孕周和产前诊断胎儿缺陷情况等。结果在110 270名孕妇中,产前诊断胎儿严重缺陷终止妊娠作引产有601例,引产率为0.55%,其中74.04%在孕周<28周时引产。年龄<20岁、20岁~、30岁~和≥35岁孕妇引产率分别为0.30%、0.52%、0.70%和0.92%,不同年龄组孕妇因产前诊断胎儿严重出生缺陷的引产率差异有统计学意义(P<0.01);前5位产前诊断胎儿出生缺陷疾病分别是心血管系统异常(18.14%)、神经系统异常(16.81%)、颜面畸形(13.48%)、泌尿系统异常(10.32%)、和染色体异常(8.32%)。结论≥35岁孕妇产前诊断胎儿出生缺陷终止妊娠率较高,需不断优化胎儿出生缺陷检查技术和流程,严格把握终止妊娠的指征。
OBJECTIVE: To understand the characteristics of prenatal diagnosis of fetus with termination of pregnancy and explore the mode of early detection and intervention. Methods Jiaxing Maternal and Child Health Hospital from October 2012 to September 2014 prenatal diagnosis of fetal serious defects in 601 cases of termination of pregnancy, maternal age, gestational age and prenatal diagnosis of fetal defects and so on. Results Among 110 270 pregnant women, there were 601 prenatal diagnoses of severe fetal deaths and induction of labor induction. The induction rate was 0.55%, of which 74.04% were induced by gestational weeks <28 weeks. The maternal labor rates were 0.30%, 0.52%, 0.70% and 0.92% for pregnant women <20 years old, 20 years old, 30 years old and ≥35 years old, respectively. There were differences in the rate of induced abortion between different age groups for prenatal diagnosis of severe birth defects (P <0.01). The first five prenatal diagnoses of fetal birth defects were cardiovascular abnormalities (18.14%), nervous system abnormalities (16.81%), facial deformities (13.48%) and urinary system abnormalities %), And chromosomal abnormalities (8.32%). Conclusions The prenatal diagnosis of fetal birth defects in 35-year-old pregnant women is higher than the expected rate of termination of pregnancy. It is necessary to continuously optimize the techniques and procedures for the examination of birth defects and strictly control the indications of termination of pregnancy.