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目的总结并探讨膀胱浆细胞样移行细胞癌的病理特征、诊断和鉴别诊断及临床特点。方法采用常规HE、巴氏染色和免疫组化方法(S-P方法),光镜观察2例膀胱浆细胞样移行细胞癌,通过临床随访和文献复习对此罕见膀胱肿瘤进行讨论。结果其特点是除粘膜有原位癌外,肿瘤多侵犯固有膜和／或肌层。细胞形态和浆细胞相似。肿瘤细胞高表达AEI／AE3,CEA和CK18。临床预后较一般的移行细胞癌差。结论膀胱浆细胞样移行细胞癌罕见,具有其特有的组织病理学和生物学特点,诊断膀胱肿瘤时应考虑到该肿瘤的可能性。
Objective To summarize and explore the pathological features, diagnosis and differential diagnosis of bladder plasmacytoid transitional cell carcinoma and its clinical features. Methods Two cases of transitional cell carcinoma of the bladder plasma were observed by light microscopy using conventional HE, Papanicolaou staining and immunohistochemistry (S-P method). This rare bladder tumor was discussed through clinical follow-up and literature review. The results of its characteristic is that in addition to mucosal carcinoma in situ, the tumor invades the inherent membrane and / or muscle. Cell morphology and plasma cells similar. Tumor cells overexpress AEI / AE3, CEA and CK18. Clinical prognosis worse than the general transitional cell carcinoma. Conclusions Bladder plasmacytoid transitional cell carcinoma is rare and has its own unique histopathological and biological features. The diagnosis of bladder cancer should consider the possibility of the tumor.