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Organ systems with proliferating cells are most sensitive, the testis is a radiosensitive organ in the body[1]. Because, proliferating spermatogonia and spermatocytes are ones of the most radiosensitive cells[2]. High LET radiation kills more cells at the same dose compared to low LET radiation. Chromosomal aberrations of spermatogonia and spermatocytes which induced radiation can be transmitted into spermatozoa[2], these effects cause asthenospermia, hypospermia, teratospermia and decrease in testis weight etc[3]. These effects are expressed after fertilization in different ways such as dominant lethal mutations, foetal abnormalities or the increased suseptibility of the offspring to carcinogens[4]. Here we performed the impact of high-dose carbon ion irradiation on testis after one spermatogenic cycle in period of infancy mice.
Organ systems with proliferating cells are most sensitive, the testis is a radiosensitive organ in the body [1]. Because proliferating spermatogonia and spermatocytes are ones of the most radiosensitive cells [2]. High LET radiation kills more cells at the same dose compared to low LET radiation. Chromosomal aberrations of spermatogonia and spermatocytes which induced radiation can be transmitted into spermatozoa [2], these effects cause asthenospermia, hypospermia, teratospermia and decrease in testis weight etc [3]. These effects are expressed after fertilization in different ways such as as dominant lethal mutations, foetal abnormalities or the increased suseptibility of the offspring to carcinogens [4]. Here we performed the impact of high-dose carbon ion irradiation on testis after one spermatogenic cycle in period of infancy mice.