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一氧化氮(NO)是体内重要的信使分子,其参与血管、气道平滑肌的调节、神经递质的传递、细胞杀伤、肿瘤细胞的溶解及内分泌激素的释放等众多过程,与多种疾病的发生、发展密切相关。诱导型一氧化氮合酶(iNOS)可在细胞因子等的刺激下催化生成NO,进而调节多种生物学功能,近年来研究表明iNOS及其催化生成的NO对多种寄生虫具有杀伤作用,表明其在抗寄生虫感染中具有重要作用。因此,本文就近年来iNOS和NO在抗寄生虫感染中的作用及机制以及影响iNOS表达的相关因素作一综述,为临床抗寄生虫药物的研发提供新的思路和方向。
Nitric oxide (NO) is an important messenger molecule in the body. It is involved in many processes such as the regulation of blood vessels and airway smooth muscle, the transmission of neurotransmitters, cell killing, the dissolution of tumor cells and the release of endocrine hormones, Occurrence, development is closely related. Inducible nitric oxide synthase (iNOS) can catalyze the production of NO under the stimulation of cytokines and the like, thereby regulating a variety of biological functions. In recent years, studies have shown that iNOS and its catalyzed production of NO exert a killing effect on various parasites, It shows that it plays an important role in anti-parasitic infection. Therefore, this review summarizes the roles and mechanisms of iNOS and NO in anti-parasitic infections in recent years and the related factors that influence the expression of iNOS, providing new ideas and directions for the development of clinical anti-parasitic drugs.