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高血压病人及其子女RBC和WBC离子变化早有报道,但机制不清,结果不一。本文用单核白细胞(MNL)作细胞模型在体外测定细胞容积,钠钾含量,钠外流率常数及钠外流绝对值,以了解有原发性高血压发病危险的青年男性细胞水平的变化并探讨这些变化是否与临界高血压和/或遗传有关。受试者均经严格血压测定以保证同质和比较。与RBC相比,MNL在超微结构,代谢和离子转运上更接近其它体细胞。分组:88例青年男性(17～40岁)分为4组。48例高血压病人子女中28例血压正常(NTO),20例为临界高血压(BHO);40例父母血压正常,其中12例临界高血压(BH),28例血压正常
Hypertensive patients and their children RBC and WBC ion changes have long been reported, but the mechanism is unclear, the results vary. In this study, mononuclear leukocyte (MNL) was used as a cell model to determine the changes of cell volume, sodium and potassium, sodium efflux rate constant and the absolute value of sodium efflux in vitro in order to understand the changes of the cellular level of young men at risk of developing essential hypertension Whether these changes are associated with borderline hypertension and / or heredity. Subjects undergo rigorous blood pressure measurements to ensure homogeneity and comparison. Compared to RBCs, MNLs are closer to other somatic cells in ultrastructure, metabolism and ion transport. Grouping: 88 young men (17 to 40 years old) were divided into 4 groups. Of the 48 hypertensive patients, 28 were normotensive (NTO) and 20 were critical hypertensive (BHO). Forty of the parents had normotensive blood pressure, of which 12 were hypertensive (BH), 28 were normotensive