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目的探讨增殖细胞核抗原 (PCNA)在肺鳞状细胞癌 (简称肺鳞癌 )组织中的表达及其与预后的关系。方法 5 1例手术切除的肺鳞癌组织 ,采用免疫组化 (SP)法检测PCNA在不同临床分期及分化程度癌组织中的表达 ,应用t检验、方差分析 (F检验 )比较其差异 ;采用Spearman等级相关分析其相关性。生存率分析采用Kaplan Meir曲线 ,Long Ranktest检验生存期的差异。结果PCNA表达在不同临床分期及分化程度间差异均具显著意义 (P <0 0 5 )。PCNA、临床分期及分化程度与生存期均呈正相关 ,PCNA指数 >5 0 %组生存期明显短于PCNA指数 <5 0 %组 (P <0 0 1)。结论PCNA在一定程度上可以作为评价肺鳞癌预后的指标。
Objective To investigate the expression of proliferating cell nuclear antigen (PCNA) in lung squamous cell carcinoma (referred to as lung squamous cell carcinoma) and its relationship with prognosis. Methods 51 cases of surgically resected lung squamous cell carcinoma were used to detect the expression of PCNA in different clinical stages and differentiating degree of cancer tissues by immunohistochemistry (SP) method. The difference was analyzed by t test and variance analysis (F test); Spearman rank correlation analyzes its relevance. Kaplan Meir curves were used for survival analysis and Long Ranktest was used to test for differences in survival. Results There was a significant difference in PCNA expression between different clinical stages and differentiation degrees (P < 0.05). There was a positive correlation between PCNA, clinical stage and differentiation degree and survival time. The survival period in PCNA index >50% group was significantly shorter than that in PCNA index <50% group (P < 0 01). Conclusion PCNA can be used as an index to evaluate the prognosis of lung squamous cell carcinoma to some extent.