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近年随着细胞与细胞、细胞与细胞外基质粘附机制逐渐被阐明,参与、介导这一粘附机制的一类细胞粘附分子以及粘附蛋白正引起人们极大关注。已证明这些粘附分子参与淋巴细胞分化,游走及移巢;白细胞炎灶部位移动及浸润;免疫细胞阃的抗原提呈及信号传递;效应细胞对靶细胞的杀伤以及肿瘤细胞的浸润及转移等。细胞粘附分子与肾脏疾病特别是肾小球肾炎发生、发展的关系已成为研究热点。有选择性地调节或抑制细胞粘附分子表达及活性,可望在阻止肾炎时炎性细胞浸润、损伤以及肾内细胞增殖乃至小球硬化等方面获得效果。而抗 ICAM-1等抗粘附分子单抗在实验性脏器移植及肾炎中使用有效性,将会随着细胞粘附机制不断被阐明而成为肾脏病有效治疗手段之一。
In recent years, with the cell and cell, cell and extracellular matrix adhesion mechanisms gradually elucidated, involved in and mediated this adhesion mechanism of a class of cell adhesion molecules and adhesion proteins are causing great concern. It has been demonstrated that these adhesion molecules are involved in lymphocyte differentiation, migration and nesting; movement and infiltration of leukocyte motoneurons; antigen presentation and signal transduction of immune cells; killing of target cells by effector cells and infiltration and metastasis of tumor cells Wait. The relationship between cell adhesion molecules and renal diseases, especially glomerulonephritis, has become a research hotspot. Selectively regulate or inhibit the expression of cell adhesion molecules and activity, is expected to prevent nephritis in inflammatory cell infiltration, injury and renal cell proliferation and even the effects of small ball hardening. The anti-ICAM-1 and other anti-adhesion molecule monoclonal antibody in experimental organ transplantation and nephritis, the effectiveness of the cell adhesion mechanism will continue to be elucidated as one of the effective treatment of kidney disease.