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阿霉素(ADR)诱导的肾病综合征模型已广泛应用于肾脏病的研究,并成为肾病研究的重要手段[1～3]。该模型类似于人类微小病变型肾病的临床表现,为进一步了解该模型大鼠蛋白代谢状态,我们采用分子杂交方法对其肝白蛋白基因转录进行了研究,报道如下。 材料与方法 1药物与试剂(1)[α-
Adriamycin (ADR) -induced nephrotic syndrome model has been widely used in kidney disease research, and become an important means of kidney disease research [1-3]. This model is similar to the clinical manifestations of human minimal change nephropathy. To further understand the protein metabolic status of this model rat, we used molecular hybridization to study the gene transcription of hepatic albumin, which is reported as follows. Materials and Methods 1 Drugs and Reagents (1) [α-