论文部分内容阅读
目的：研究硫芥中毒对大鼠的止、凝血功能的影响机制。方法：建立大鼠硫芥中毒模型，注射 １／４ＬＤ５０硫芥 ７ ｄ后测定血红蛋白（Ｈｂ）、血小板计数（ＰＬＣ）、有核细胞计数（ＮＣ）、凝血酶原时间（ＰＴ）、活化部分凝血活酶时间（ＡＰＴＴ）、纤维结合蛋白（ＦＮ）、纤溶酶（Ｐｌｍ）等指标。结果：硫芥组及各治疗组大鼠 Ｈｂ、ＰＬＣ、ＮＣ明显低于对照组。硫芥中毒组大鼠血清 ＦＮ低于对照组，ＥＰＯ加用四药治疗组ＦＮ明显高于硫芥中毒组和其他治疗组。硫芥中毒组ＡＰＴＴ、ＰＴ均比其他各组延长。结论：硫芥中毒可导致大鼠ＰＬＣ、Ｈｂ，ＦＮ减少及内、外源凝血功能降低；促红细胞生成素（ＥＰＯ）对ＦＮ合成有促进作用。
Objective: To study the mechanism of the effects of sulfur mustard poisoning on the clotting and coagulation function in rats. Methods: The rat model of sulfur mustard poisoning was established. The hemoglobin (Hb), platelet count (NC), prothrombin time (PT), activated partial thrombosis Live enzyme time (APTT), fibronectin (FN), plasmin (Plm) and other indicators. Results: Hb, PLC and NC in sulfur mustard group and each treatment group were significantly lower than those in control group. The serum FN in the sulfur mustard poisoning group was lower than that in the control group, and the FN in the EPO plus four-drug treatment group was significantly higher than those in the sulfur mustard poisoning group and other treatment groups. Sulfur mustard poisoning group APTT, PT were longer than the other groups. CONCLUSION: Sulfur mustard poisoning can result in the decrease of PLC, Hb, FN and the decrease of coagulation function in both exogenous and in vivo. Erythropoietin (EPO) can promote the synthesis of FN.