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目的综合评价血管紧张素转换酶(ACE)基因多态性与阻塞性睡眠呼吸暂停综合征(OSAS)合并高血压的关系。方法检索Pub Med、Cochrane Library、中国学术期刊全文数据库、中国生物医学文献数据库、万方资源数据库、重庆维普网并手工检索相关期刊,全面收集ACE基因多态性与OSAS合并高血压关系的病例对照研究文献,提取有效数据进行Meta分析。结果最终纳入4篇文献。Meta分析结果显示:亚洲人群的OSAS合并高血压组D/Ⅰ和DD/Ⅱ分布的合并OR分别为0.59(95%CI:0.39~0.89,P=0.011)和0.40(95%CI:0.16~0.98,P=0.044)。结论亚洲人群ACE基因多态性与OSAS合并高血压易感性有关。但因研究质量及研究样本的存在明显局限性,需更多高质量、大规模的临床研究加以验证。
Objective To evaluate the relationship between angiotensin converting enzyme (ACE) gene polymorphism and obstructive sleep apnea syndrome (OSAS) and hypertension. Methods PubMed, Cochrane Library, China Academic Journal Full-text Database, China Biomedical Literature Database, Wanfang Resource Database, Chongqing VipNet were searched and related journals were searched manually to collect case-control data of ACE gene polymorphism and OSAS with hypertension Research literature, extract valid data for meta-analysis. The results eventually included 4 articles. Meta-analysis showed that the combined odds ratio (OR) of D / I and DD / II distribution in Asian OSAS patients with hypertension was 0.59 (95% CI: 0.39-0.89, P = 0.011) and 0.40 (95% CI 0.16-0.98 , P = 0.044). Conclusion The ACE gene polymorphism in Asian population is associated with the susceptibility to hypertension in OSAS. However, due to the obvious limitations of research quality and research samples, more high-quality and large-scale clinical studies are needed to verify this.