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利用体内１９ＦＮＭＲ研究了５─氟尿嘧啶在小鼠肝脏及植入肿瘤组织中的代谢过程．５─氟尿嘧啶在肝脏中的生物半衰期为１５～２０ｍｉｎ，而在Ｓ１８０肿瘤中的生物半衰期为５０─６０ｍｉｎ．除５─氟尿嘧啶的信号外．在肝脏中观测到了５─氟尿嘧啶的分解代谢产物ＦＵＰＡ和ＦＢＡＬ，而在肿瘤中则只有合成代谢产物氟代核苷酸的信号．实验结果表明．核磁共振是研究药物在体内代谢过程的有力方法．
The in vivo 19F NMR study of 5-fluorouracil in mouse liver and tumor tissue implanted in the metabolic process. The biological half-life of 5-fluorouracil in the liver is 15-20 min, whereas the biological half-life in S180 tumors is 50- 60 min. In addition to 5-fluorouracil signal. In the liver, 5-Fluorouracil catabolites FUPA and FBAL were observed, whereas in tumors only the signal for the synthesis of the metabolite fluorotribonucleotide was observed. Experimental results show. Nuclear magnetic resonance is a powerful way to study the metabolic processes in the body.